Abstract
Tuberculosis either caused by Mycobacterium bovis or M. caprae is a significant burden to agricultural industries worldwide. Vaccination of domestic ruminant species such as cattle and goats constitutes a potential tool to support disease control. This review will discuss recent progress made to develop tuberculosis vaccines against domestic ruminants as well as approaches to differentiate vaccinated and infected animals (DIVA) and biomarker discovery studies.
Keywords:
Biomarkers; Cattle; DIVA; Goats; Tuberculosis; Vaccination.
Crown Copyright © 2014. Published by Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Animals, Domestic*
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BCG Vaccine / immunology
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BCG Vaccine / therapeutic use
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Cattle
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Diagnosis, Differential
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Europe
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Goat Diseases / diagnosis
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Goat Diseases / immunology
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Goat Diseases / prevention & control*
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Goats
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Mycobacterium bovis / immunology
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Mycobacterium tuberculosis / immunology
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Ruminants
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Tuberculosis / immunology
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Tuberculosis / prevention & control
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Tuberculosis / veterinary*
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Tuberculosis Vaccines / immunology
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Tuberculosis Vaccines / therapeutic use*
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Tuberculosis, Bovine / diagnosis
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Tuberculosis, Bovine / immunology
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Tuberculosis, Bovine / prevention & control*
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Vaccination / trends
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Vaccination / veterinary*
Substances
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BCG Vaccine
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Tuberculosis Vaccines