First identification and quantification of lorcaserin in an herbal slimming dietary supplement

Rabab Hachem; Myriam Malet-Martino; Véronique Gilard

doi:10.1016/j.jpba.2014.05.003

First identification and quantification of lorcaserin in an herbal slimming dietary supplement

J Pharm Biomed Anal. 2014 Sep:98:94-9. doi: 10.1016/j.jpba.2014.05.003. Epub 2014 May 14.

Authors

Rabab Hachem¹, Myriam Malet-Martino¹, Véronique Gilard²

Affiliations

¹ Groupe de RMN Biomédicale, Laboratoire SPCMIB (UMR CNRS 5068), Université Paul Sabatier, Université de Toulouse, 118 route de Narbonne, 31062 Toulouse cedex, France.
² Groupe de RMN Biomédicale, Laboratoire SPCMIB (UMR CNRS 5068), Université Paul Sabatier, Université de Toulouse, 118 route de Narbonne, 31062 Toulouse cedex, France. Electronic address: gilard@chimie.ups-tlse.fr.

PMID: 24905289
DOI: 10.1016/j.jpba.2014.05.003

Abstract

The weight-loss drug lorcaserin, a FDA approved anorectic drug, was isolated from the dietary supplement "Lose quickly" claimed to be a pure natural fast slimming diet pill. After its purification by means of preparative liquid chromatography, its structure was characterized using LC-UV, NMR, MS, MS/MS, and IR spectroscopy. The amount of lorcaserin measured by qNMR was 6.6mg/capsule.

Keywords: Adulteration; Lorcaserin; Mass Spectrometry (MS); Nuclear Magnetic Resonance (NMR); Slimming dietary supplements.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Benzazepines / chemistry*
Chromatography, Liquid / methods
Dietary Supplements / analysis*
Herbal Medicine / methods
Magnetic Resonance Spectroscopy / methods
Tandem Mass Spectrometry / methods

Substances

Benzazepines
lorcaserin