Unusual redo mitral valve replacement for bleeding in Glanzmann thrombasthenia

Asian Cardiovasc Thorac Ann. 2016 Jan;24(1):57-9. doi: 10.1177/0218492314539333. Epub 2014 Jun 5.

Abstract

We report the case of 23-year-old man with mitral valve regurgitation and Glanzmann thrombasthenia, who underwent mechanical mitral valve replacement. Warfarin therapy was devastating, causing bilateral hemothorax, pericardial effusion, gastrointestinal bleeding, and hematuria. Redo mitral valve replacement with a biological prosthesis was required to resolve this critical situation. To our knowledge, this is the first report of mitral valve replacement in Glanzmann thrombasthenia, highlighting the danger of oral anticoagulation in this pathology.

Keywords: Bioprosthesis; Glanzmann thrombasthenia; Heart valve prothesis implantation; Mitral valve; Thrombasthenia; Warfarin; autosomal dominant.

Publication types

  • Case Reports

MeSH terms

  • Administration, Oral
  • Anticoagulants / administration & dosage
  • Anticoagulants / adverse effects*
  • Bioprosthesis
  • Blood Coagulation* / genetics
  • Device Removal
  • Gastrointestinal Hemorrhage / chemically induced
  • Heart Valve Prosthesis
  • Heart Valve Prosthesis Implantation* / instrumentation
  • Hematuria / chemically induced
  • Humans
  • Male
  • Mitral Valve / surgery*
  • Mitral Valve Insufficiency / complications
  • Mitral Valve Insufficiency / diagnosis
  • Mitral Valve Insufficiency / surgery*
  • Pericardial Effusion / chemically induced
  • Postoperative Hemorrhage / chemically induced*
  • Postoperative Hemorrhage / diagnosis
  • Prosthesis Design
  • Reoperation
  • Risk Factors
  • Thrombasthenia / blood
  • Thrombasthenia / complications*
  • Thrombasthenia / diagnosis
  • Treatment Outcome
  • Warfarin / administration & dosage
  • Warfarin / adverse effects*
  • Young Adult

Substances

  • Anticoagulants
  • Warfarin