Abstract
Merkel cell carcinoma (MCC) is recognized by its morphologic features and by its classic immunophenotypic properties. Although MCCs demonstrating nonclassic immunoreactivities have been described, a case documenting a change in immunophenotype during the course of disease progression has not been previously reported. We report a case of MCC that initially demonstrated cytokeratin 20 positivity but lost expression in subsequent metastases. Likewise, thyroid transcription factor-1 was initially negative in the tumor but expression was present in metastatic lesions.
Publication types
-
Case Reports
-
Research Support, N.I.H., Extramural
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Aged
-
Biomarkers, Tumor / analysis*
-
Biopsy
-
Brain Neoplasms / chemistry*
-
Brain Neoplasms / secondary*
-
Brain Neoplasms / therapy
-
Carcinoma, Merkel Cell / chemistry*
-
Carcinoma, Merkel Cell / secondary*
-
Carcinoma, Merkel Cell / therapy
-
Disease Progression
-
Humans
-
Immunohistochemistry
-
Keratin-20 / analysis
-
Male
-
Nuclear Proteins / analysis*
-
Predictive Value of Tests
-
Skin Neoplasms / chemistry*
-
Skin Neoplasms / pathology
-
Skin Neoplasms / therapy
-
Thyroid Nuclear Factor 1
-
Transcription Factors / analysis*
Substances
-
Biomarkers, Tumor
-
KRT20 protein, human
-
Keratin-20
-
NKX2-1 protein, human
-
Nuclear Proteins
-
Thyroid Nuclear Factor 1
-
Transcription Factors