Novel 2-aminobenzamides as potential orally active antithrombotic agents

Amit Verma; Rajani Giridhar; Ashish Kanhed; Anshuman Sinha; Pratik Modh; Mange R Yadav

doi:10.1021/ml300217f

Novel 2-aminobenzamides as potential orally active antithrombotic agents

ACS Med Chem Lett. 2012 Oct 31;4(1):32-6. doi: 10.1021/ml300217f. eCollection 2013 Jan 10.

Authors

Amit Verma¹, Rajani Giridhar¹, Ashish Kanhed¹, Anshuman Sinha¹, Pratik Modh¹, Mange R Yadav¹

Affiliation

¹ Pharmacy Department, Faculty of Technology & Engineering, Kalabhavan, The M. S. University of Baroda , Vadodara, 390001 Gujarat, India.

Abstract

In an effort to develop potent antithrombotic agents, a series of novel 2-aminobenzamide derivatives were synthesized and screened for their in vivo antithrombotic activity. Among the 23 compounds tested, compound (8g) showed the most promising antithrombotic activity, which was comparable with clinically used aspirin or warfarin, but at variance with these standard drugs, 8g did not exhibit the increased bleeding time, suggesting its potential as a novel antithrombotic agent.

Keywords: 2-aminobenzamide; antiplatelet; antithrombotic agents; ionic liquid; thromboembolic disorders.

Publication types

Retracted Publication