Abstract
Herein, we present a fluorescent-peptide drug delivery system composed of biotin-naphthalimide-HJ inhibitor peptide2, prodrug 1. Treatment of 1 to biotin receptor-positive HepG2 cells, which are resistant to high concentrations of the HJ inhibitor peptide2, decreased cell viability and increased intracellular fluorescence.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / administration & dosage*
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Antineoplastic Agents / chemistry
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Biotin / administration & dosage*
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Biotin / chemistry
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Cell Survival / drug effects
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Cell Survival / physiology
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Drug Delivery Systems / methods*
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Fluorescent Dyes / administration & dosage*
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Fluorescent Dyes / chemistry
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Hep G2 Cells
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Humans
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Peptides / administration & dosage*
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Peptides / chemistry
Substances
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Antineoplastic Agents
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Fluorescent Dyes
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Peptides
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Biotin