Triglyceride-lowering agents

Nariman F Salakhutdinov; Sergey S Laev

doi:10.1016/j.bmc.2014.05.008

Triglyceride-lowering agents

Bioorg Med Chem. 2014 Jul 15;22(14):3551-64. doi: 10.1016/j.bmc.2014.05.008. Epub 2014 May 13.

Authors

Nariman F Salakhutdinov¹, Sergey S Laev²

Affiliations

¹ Vorozhtsov Institute of Organic Chemistry, Siberian Division, Russian Academy of Sciences, pr. akademika Lavrent'eva 9, Novosibirsk 630090, Russian Federation; Novosibirsk State University, Pirogova str. 2, Novosibirsk 630090, Russian Federation.
² Vorozhtsov Institute of Organic Chemistry, Siberian Division, Russian Academy of Sciences, pr. akademika Lavrent'eva 9, Novosibirsk 630090, Russian Federation. Electronic address: sergey@nioch.nsc.ru.

PMID: 24894768
DOI: 10.1016/j.bmc.2014.05.008

Abstract

This review is the first attempt at systematization of the literature data on the structures and activities of triglyceride-lowering agents which used in medical practice or are in development. The effects and mechanisms of action of statins, squalene synthase inhibitors, fibrates, PPARα and PPARα/γ agonists, nicotinic acid, omega-3 fatty acids and some other molecular targets were considered. Unfortunately, to date, harmless and effective triglyceride-lowering drug still does not exist and there is still need for development of better triglyceride-lowering agents.

Keywords: Fibrates; Nicotinic acid; Omega-3 fatty acids; PPARα and PPARα/γ agonists; Squalene synthase inhibitors; Statins; Triglyceride-lowering agents.

Publication types

Review

MeSH terms

Animals
Cholesterol / biosynthesis
Cholesterol / metabolism*
Enzyme Inhibitors / chemistry
Enzyme Inhibitors / pharmacology*
Enzymes / metabolism
Humans
Peroxisome Proliferator-Activated Receptors / agonists*
Triglycerides / chemistry
Triglycerides / pharmacology*

Substances

Enzyme Inhibitors
Enzymes
Peroxisome Proliferator-Activated Receptors
Triglycerides
Cholesterol