Engaging in regular physical activity is a key component for maintaining a healthy weight and preventing overweight and obesity. Obesity continues to be a concern globally, especially for women, and women are less physically active than men. This systematic review examined current research on physical activity interventions designed for healthy community dwelling women and assessed the effects of those interventions on physical activity and body composition. Three author-developed data collection tools were used to extract and examine study variables. For studies with suitable data, effect sizes were obtained. The initial search identified 1,406 titles published between 2000 and 2012, of which 40 randomized clinical trials met inclusion criteria. Of these 40 studies, 16 had a physical activity intervention that did not have a diet component and 24 had a physical activity intervention along with a diet component. The overall weighted mean effect was d = .21, 95% CI [0.06, 0.36] for physical activity outcomes (n = 18 studies) and d = -.16, 95% CI [-0.22, -0.09] for body composition outcomes (n = 24 studies). Both physical activity interventions without and with a diet component were effective in promoting physical activity and improving body composition. Physical activity interventions without a diet component were more effective than physical activity interventions with a diet component at promoting physical activity. The most effective interventions need to be adapted for dissemination into practice.