Cytotoxic 9,19-cycloartane triterpenes from the aerial parts of Cimicifuga yunnanensis

Abstract

Six new 9,19-cycloartane triterpenes (1-6) were isolated from the aerial parts of Cimicifuga yunnanensis. The new chemical structures were determined by extensive analyses of 1D and 2D NMR spectroscopy. Compounds 1 and 2 are the first 9,19-cycloartane triterpenes characterized by CH₃-18 shifting from C-13 to C-12 in the Cimicifuga spp. The evaluation of inhibition activity against human HL-60, SMMC-7721, A-549, MCF-7, and SW480 cell lines indicated that compounds 1-6 showed different levels of cytotoxic activities with IC₅₀ values ranging from 1.2 to 27.8 μm.

Keywords: 18(13→12)Abeo-9,19-cycloartane triterpenes; Cimicifuga yunnanensis; Cytotoxicity.