Towards aryl C-N bond formation in dynamic thin films

Org Biomol Chem. 2014 Jul 14;12(26):4594-7. doi: 10.1039/c4ob00926f.

Abstract

C-N bond forming reactions are important in organic chemistry. A thin film microfluidic vortex fluidic device (VFD) operating under confined mode affords N-aryl compounds from 2-chloropyrazine and the corresponding amine, without the need for a transition metal catalyst.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amines / chemical synthesis
  • Amines / chemistry*
  • Catalysis
  • Chemical Phenomena*
  • Microfluidics
  • Morpholines / chemistry
  • Palladium / chemistry
  • Pyrazines / chemistry

Substances

  • 2-chloropyrazine
  • Amines
  • Morpholines
  • Pyrazines
  • Palladium