Fluorination of flavones and chromones using elemental fluorine

J Org Chem. 2014 Aug 15;79(16):7261-5. doi: 10.1021/jo5009542. Epub 2014 Jun 12.

Abstract

Flavonoids are abundant micronutrients in our diet, possessing various biological activities. Fluorine was successfully added across the double bond of various flavones and chromones. The difluoro derivative products were easily dehydrofluorinated to form the corresponding 3-fluoroflavones and 3-fluorochromones.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biological Products / chemistry*
  • Chromones / chemistry*
  • Flavones / chemistry*
  • Flavonoids / chemistry*
  • Fluorine / chemistry*
  • Magnetic Resonance Spectroscopy
  • Molecular Structure

Substances

  • 3-fluoro-5-hydroxy-7-acetoxyflavone
  • Biological Products
  • Chromones
  • Flavones
  • Flavonoids
  • Fluorine