Erythrodermic psoriasis with bullous pemphigoid: combination treatment with methotrexate and compound glycyrrhizin

Diagn Pathol. 2014 May 29:9:102. doi: 10.1186/1746-1596-9-102.

Abstract

We report a case of erythrodermic psoriasis with bullous pemphigoid (BP) in a 68-year-old male. The patient had a history of psoriasis for 35 years and tense, blisterlike lesions for 4 months. He presented with diffuse flushing, infiltrative swelling, and tense blisterlike lesions on his head, trunk, and limbs. This patient was successfully treated by a combination of methotrexate and compound glycyrrhizin. We also discuss the clinical manifestations, histopathological features, and differentiation of erythrodermic psoriasis with BP and present a review of the pertinent literature.

Virtual slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1853737109114076.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Biopsy
  • Dermatitis, Exfoliative / diagnosis
  • Dermatitis, Exfoliative / drug therapy*
  • Dermatologic Agents / therapeutic use*
  • Drug Therapy, Combination
  • Glycyrrhizic Acid / therapeutic use*
  • Humans
  • Male
  • Methotrexate / therapeutic use*
  • Microscopy, Fluorescence
  • Pemphigoid, Bullous / diagnosis
  • Pemphigoid, Bullous / drug therapy*
  • Psoriasis / diagnosis
  • Psoriasis / drug therapy*
  • Skin / drug effects*
  • Skin / pathology
  • Treatment Outcome

Substances

  • Dermatologic Agents
  • Glycyrrhizic Acid
  • Methotrexate