The emerging role of soluble HLA-G in the control of chemotaxis

Cytokine Growth Factor Rev. 2014 Jun;25(3):327-35. doi: 10.1016/j.cytogfr.2014.04.004. Epub 2014 May 13.

Abstract

HLA-G is an immunosuppressive molecule, that impairs the function of different immune cell populations, both in physiological and pathological conditions. Here, we have analyzed data obtained by our group and others regarding sHLA-G concentration in plasma from patients with different diseases. Next, we have summarized novel data regarding the impairment of chemotaxis of different immune effector cells mediated by sHLA-G. Finally, we have discussed the impact of this function on the immune response during cancer, viral infection, autoimmunity, and on B cell differentiation in secondary lymphoid organs. In conclusion, we have delineated a role of sHLA-G in the control of chemotaxis of immune effector cells, that may be relevant to modulate immune responses in different settings.

Keywords: Chemokine receptors; Chemotaxis; HLA-G.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Autoimmune Diseases / immunology*
  • Autoimmune Diseases / pathology
  • B-Lymphocytes / immunology*
  • B-Lymphocytes / pathology
  • Cell Differentiation / immunology
  • Chemotaxis / immunology*
  • HLA-G Antigens / immunology*
  • Humans
  • Neoplasms / immunology*
  • Neoplasms / pathology
  • Solubility
  • Virus Diseases / immunology*
  • Virus Diseases / pathology

Substances

  • HLA-G Antigens