Acute myeloid leukemia concurrent with spinal epidural extramedullary myeloid sarcoma accompanied by a high CD25 expression and the FLT3-ITD mutation

Intern Med. 2014;53(11):1159-64. doi: 10.2169/internalmedicine.53.1137. Epub 2014 Jun 1.

Abstract

Myeloid sarcoma (MS) is an extramedullary myeloid tumor that sometimes presents with antedating systemic leukemia, leading physicians to the misdiagnosis of lymphoma. CD25 is expressed in 13% of patients with acute myeloid leukemia (AML), and its expression is associated with FLT3-ITD mutations, an elevated serum soluble interleukin 2 receptor (sIL-2R) level and a lower survival rate. However, there are no reports concerning the relationship between MS and the CD25 expression. We herein report a case of AML accompanied by thoracic epidural MS with a high CD25 expression, the FLT3-ITD mutation and an extremely elevated serum sIL-2R level in a 59-year-old man who presented with paraplegia.

Publication types

  • Case Reports

MeSH terms

  • Bone Marrow / pathology
  • Humans
  • Interleukin-2 Receptor alpha Subunit / metabolism*
  • Leukemia, Myeloid, Acute* / genetics
  • Leukemia, Myeloid, Acute* / metabolism
  • Male
  • Middle Aged
  • Mutation
  • Neoplasms, Multiple Primary* / genetics
  • Neoplasms, Multiple Primary* / metabolism
  • Paraplegia / etiology
  • Radiography
  • Sarcoma, Myeloid* / diagnostic imaging
  • Sarcoma, Myeloid* / pathology
  • Spinal Neoplasms* / diagnostic imaging
  • Spinal Neoplasms* / pathology
  • Thoracic Vertebrae / diagnostic imaging
  • fms-Like Tyrosine Kinase 3 / genetics*

Substances

  • Interleukin-2 Receptor alpha Subunit
  • FLT3 protein, human
  • fms-Like Tyrosine Kinase 3