Differential impact on acute kidney injury incidence between on- and off pump coronary artery bypass grafting in octogenarians

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015 Sep;159(3):449-54. doi: 10.5507/bp.2014.023. Epub 2014 May 30.

Abstract

Introduction: Acute kidney injury (AKI) following surgical myocardial revascularization is associated with high mortality and morbidity. The aim of this study was to evaluate the risk of acute kidney injury in a population of very old patients following different surgical techniques.

Patients and methods: A retrospective study of 310 consecutive patients aged 78 to 93 years, mean 80.5±2.2, who underwent surgery at one cardiac surgery centre. Based on the surgical technique used the patients were divided into: Group I. CABG (n=134) - surgical myocardial revascularization using extracorporeal circulation and arterial and venous grafts. Group II. OPCABG (n=55) - surgical revascularization without extracorporeal circulation but using arterial and venous grafts. Group III. NOTOUCH (n=121) - no handling with the ascending aorta was performed at all.

Results: A statistically insignificant renoprotective trend was found in patients who underwent surgery without extracorporeal circulation regardless of technique. Comparing groups II and III vs. group I, a significantly poorer renal functioning (median difference in creatinine was 10.0 (32.9) vs 17.5 (35.0), P=0.05) was shown for patients in group I.

Conclusion: Surgical myocardial revascularization without extracorporeal circulation in very old patients is safe. The results of this study show a renoprotective trend.

Keywords: acute kidney injury; coronary artery bypass grafting; octogenarians.

MeSH terms

  • Acute Kidney Injury / epidemiology*
  • Acute Kidney Injury / etiology
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Coronary Artery Bypass / adverse effects
  • Coronary Artery Bypass, Off-Pump / adverse effects
  • Coronary Artery Disease / surgery*
  • Czech Republic / epidemiology
  • Female
  • Humans
  • Incidence
  • Male
  • Postoperative Complications / epidemiology*
  • Retrospective Studies
  • Risk Assessment*
  • Risk Factors