ICAM-1 and SRD5A1 gene polymorphisms in symptomatic peripheral artery disease

Vincenza Barresi; Salvatore S Signorelli; Nicolò Musso; Massimiliano Anzaldi; Valerio Fiore; Mario Alberghina; Daniele Filippo Condorelli

doi:10.1177/1358863X14532705

ICAM-1 and SRD5A1 gene polymorphisms in symptomatic peripheral artery disease

Vasc Med. 2014 Jun;19(3):175-181. doi: 10.1177/1358863X14532705. Epub 2014 May 30.

Authors

Vincenza Barresi¹, Salvatore S Signorelli², Nicolò Musso¹, Massimiliano Anzaldi², Valerio Fiore², Mario Alberghina³, Daniele Filippo Condorelli⁴

Affiliations

¹ Department of Bio-Medical Sciences, Section of Biochemistry, University of Catania, Catania, Italy.
² Department of Medicine and Pediatrics, University of Catania, Catania, Italy.
³ Department of Clinical and Molecular Biomedicine, University of Catania, Catania, Italy.
⁴ Department of Bio-Medical Sciences, Section of Biochemistry, University of Catania, Catania, Italy daniele.condorelli@unict.it.

PMID: 24879712
DOI: 10.1177/1358863X14532705

Abstract

The genotype distribution of two gene polymorphisms, previously associated with peripheral artery disease (PAD), has been evaluated in a population of diabetic (DPAD) and non-diabetic (NDPAD) patients affected by symptomatic PAD (stages II-IV). A decreased frequency of the AA genotype of rs5498 (ICAM-1) was observed in the PAD subjects compared to controls but this result did not reach statistical significance (p=0.06 by chi-squared test). On the contrary, a significant increase in the frequency of the GG homozygous genotype of rs248793 (SRD5A1) was observed in the PAD patient group in comparison to controls (p=0.01). These data confirm that the GG genotype of rs248793 in the SRD5A1 gene is significantly associated with symptomatic PAD and show a trend towards a stronger association with the non-diabetic status.

Keywords: ICAM1; SRD5A1; atherosclerosis; diabetes; peripheral artery disease; single nucleotide polymorphism.