Abstract
A chemo- and enantioselective cross-aza-benzoin reaction between enals and isatin-derived ketimines is disclosed. The high chemoselectivity (of the acyl anion reaction over enal α- and β-carbon reactions) is enabled by the electronic and steric properties of the N-heterocyclic carbene organocatalyst.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aza Compounds / chemistry*
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Benzoin / chemistry*
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Catalysis
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Imines / chemistry*
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Indoles / chemical synthesis*
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Indoles / chemistry
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Isatin / chemistry*
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Methane / analogs & derivatives*
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Methane / chemistry
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Molecular Structure
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Nitriles / chemistry*
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Stereoisomerism
Substances
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Aza Compounds
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Imines
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Indoles
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Nitriles
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ketimine
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carbene
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Isatin
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Benzoin
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Methane