The continual reassessment method for multiple toxicity grades: a bayesian model selection approach

PLoS One. 2014 May 29;9(5):e98147. doi: 10.1371/journal.pone.0098147. eCollection 2014.

Abstract

Grade information has been considered in Yuan et al. (2007) wherein they proposed a Quasi-CRM method to incorporate the grade toxicity information in phase I trials. A potential problem with the Quasi-CRM model is that the choice of skeleton may dramatically vary the performance of the CRM model, which results in similar consequences for the Quasi-CRM model. In this paper, we propose a new model by utilizing bayesian model selection approach--Robust Quasi-CRM model--to tackle the above-mentioned pitfall with the Quasi-CRM model. The Robust Quasi-CRM model literally inherits the BMA-CRM model proposed by Yin and Yuan (2009) to consider a parallel of skeletons for Quasi-CRM. The superior performance of Robust Quasi-CRM model was demonstrated by extensive simulation studies. We conclude that the proposed method can be freely used in real practice.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • Antineoplastic Agents / adverse effects*
  • Antineoplastic Agents / therapeutic use
  • Bayes Theorem*
  • Clinical Trials, Phase I as Topic
  • Computer Simulation
  • Humans
  • Maximum Tolerated Dose*
  • Models, Statistical*
  • Neoplasms / drug therapy

Substances

  • Antineoplastic Agents