Synergistic combination therapy using a lipid shell-droplet core nanosphere with tunable thickness

Chem Commun (Camb). 2014 Oct 7;50(77):11291-4. doi: 10.1039/c4cc02717e.

Abstract

A newly-designed drug carrier composed of an internal droplet core and a thickness-controllable shell was successfully developed. By co-delivering paclitaxel, doxorubicin and quantum dots simultaneously, this combinational drug delivery system could achieve in vitro fluorescence imaging, chemotherapeutic and oxidation therapy.

MeSH terms

  • Antibiotics, Antineoplastic / administration & dosage
  • Antineoplastic Agents, Phytogenic / administration & dosage
  • Antineoplastic Combined Chemotherapy Protocols / chemistry
  • Cell Line, Tumor
  • Doxorubicin / administration & dosage
  • Drug Carriers / chemical synthesis*
  • Drug Synergism
  • Fluorescence
  • Humans
  • Lipids / chemistry*
  • Nanospheres / chemistry*
  • Paclitaxel / administration & dosage
  • Quantum Dots
  • Reactive Oxygen Species / chemistry

Substances

  • Antibiotics, Antineoplastic
  • Antineoplastic Agents, Phytogenic
  • Drug Carriers
  • Lipids
  • Reactive Oxygen Species
  • Doxorubicin
  • Paclitaxel