Separation and enrichment of enantiopure from racemic compounds using magnetic levitation

Xiaochuan Yang; Shin Yee Wong; David K Bwambok; Manza B J Atkinson; Xi Zhang; George M Whitesides; Allan S Myerson

doi:10.1039/c4cc02604g

Separation and enrichment of enantiopure from racemic compounds using magnetic levitation

Chem Commun (Camb). 2014 Jul 18;50(56):7548-51. doi: 10.1039/c4cc02604g.

Authors

Xiaochuan Yang¹, Shin Yee Wong, David K Bwambok, Manza B J Atkinson, Xi Zhang, George M Whitesides, Allan S Myerson

Affiliation

¹ Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA. myerson@mit.edu.

PMID: 24875274
DOI: 10.1039/c4cc02604g

Abstract

Crystallization of a solution with high enantiomeric excess can generate a mixture of crystals of the desired enantiomer and the racemic compound. Using a mixture of S-/RS-ibuprofen crystals as a model, we demonstrated that magnetic levitation (MagLev) is a useful technique for analysis, separation and enantioenrichment of chiral/racemic products.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Chemistry Techniques, Analytical / methods*
Crystallization
Magnetic Fields*
Magnetic Phenomena
Particle Size*
Stereoisomerism