Mouse studies on inhibitors of Plasmodium falciparum Hsp90: progress and challenges

Abebe Genetu Bayih; Dylan R Pillai

doi:10.1017/S0031182014000754

Mouse studies on inhibitors of Plasmodium falciparum Hsp90: progress and challenges

Parasitology. 2014 Aug;141(9):1216-22. doi: 10.1017/S0031182014000754. Epub 2014 May 28.

Authors

Abebe Genetu Bayih¹, Dylan R Pillai¹

Affiliation

¹ Department of Microbiology, Immunology and Infectious Diseases, Faculty of Medicine,University of Calgary,Calgary, AB T2L 2K8,Canada.

PMID: 24871961
DOI: 10.1017/S0031182014000754

Abstract

This review highlights studies conducted in murine models to evaluate the efficacy of compounds targeting Heat shock protein (Hsp) 90 of malaria. Both advances achieved and limitations that exist are highlighted.

Publication types

Review

MeSH terms

Animals
Antimalarials / pharmacology*
Gene Expression Regulation / physiology*
HSP90 Heat-Shock Proteins / antagonists & inhibitors
HSP90 Heat-Shock Proteins / genetics
HSP90 Heat-Shock Proteins / metabolism*
Mice
Plasmodium falciparum / genetics
Plasmodium falciparum / metabolism*
Protozoan Proteins / antagonists & inhibitors
Protozoan Proteins / genetics
Protozoan Proteins / metabolism*

Substances

Antimalarials
HSP90 Heat-Shock Proteins
Protozoan Proteins