Mitochondria-targeted colorimetric and fluorescent probes for hypochlorite and their applications for in vivo imaging

Chem Commun (Camb). 2014 Aug 14;50(63):8640-3. doi: 10.1039/c4cc02673j. Epub 2014 May 29.

Abstract

Two mitochondria-targeted real-time probes were presented, which could selectively respond to hypochlorite over other ROS. Meanwhile, the "off-on" probes could be successfully applied in the in vivo imaging of hypochlorite in living mice.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Colorimetry
  • Fluorescent Dyes
  • HeLa Cells
  • Humans
  • Hypochlorous Acid / chemistry*
  • Mice
  • Mice, Nude
  • Mitochondria / chemistry*
  • Mitochondria / drug effects
  • Oxidants / chemistry
  • Reactive Oxygen Species / chemistry
  • Spectrometry, Fluorescence

Substances

  • Fluorescent Dyes
  • Oxidants
  • Reactive Oxygen Species
  • Hypochlorous Acid