From the phenotype to the genotype via bioinformatics

Cali E Willet; Claire M Wade

doi:10.1007/978-1-4939-0847-9_1

From the phenotype to the genotype via bioinformatics

Methods Mol Biol. 2014:1168:1-16. doi: 10.1007/978-1-4939-0847-9_1.

Authors

Cali E Willet¹, Claire M Wade

Affiliation

¹ Faculty of Veterinary Science, University of Sydney, Sydney, NSW, 2006, Australia.

PMID: 24870127
DOI: 10.1007/978-1-4939-0847-9_1

Abstract

Moving a project from the status of observing a trait of interest to identifying the underlying causal variant is a challenging task requiring a series of bioinformatics procedures and ideally the availability of a suitable reference genome sequence and its associated resources. We visit common practices for discovering the biology underlying observed traits in mammals.

MeSH terms

Animals
Computational Biology / methods*
Genotype*
Mammals
Phenotype*