Total synthesis of indole alkaloid (±)-subincanadine E

Jingjing Tian; Qiuchen Du; Rui Guo; Yun Li; Bin Cheng; Hongbin Zhai

doi:10.1021/ol501308p

Total synthesis of indole alkaloid (±)-subincanadine E

Org Lett. 2014 Jun 20;16(12):3173-5. doi: 10.1021/ol501308p. Epub 2014 May 28.

Authors

Jingjing Tian¹, Qiuchen Du, Rui Guo, Yun Li, Bin Cheng, Hongbin Zhai

Affiliation

¹ State Key Laboratory of Applied Organic Chemistry, Lanzhou University , Lanzhou 730000, China.

PMID: 24869784
DOI: 10.1021/ol501308p

Abstract

The first total synthesis of indole alkaloid (±)-subincanadine E has been accomplished. Ni(COD)2-mediated intramolecular Michael addition and zinc-mediated fragmentation reaction served as two key transformations.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aspidosperma / chemistry
Brazil
Indole Alkaloids / chemical synthesis*
Indole Alkaloids / chemistry
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Stereoisomerism

Substances

Indole Alkaloids
subincanadine E