Objective: To study the effect of curcumin on antioxidant function in the mice with acute alcoholic liver injury.
Methods: 50 male KM mices were randomly divided into 5 groups according to the weight, i. e. the normal control group, model control group, and curcumin low-dose group, middle-dose group, high-dose group (50, 100 and 200 mg/kg BW). After a 14-day administration, the relative liver weight, the content of MDA, the activity of SOD, GSH-Px, T-AOC in the liver tissue and the content of serum AST, ALT were determined.
Results: Compared with the normal control group, all indexes of model control group were significantly different (P < 0.05). The content of serum AST and ALT at high-dose group were significantly decreased compared with model control group (P < 0.05). Meanwhile, the activity of SOD, GSH-Px and T-AOC in the liver tissue were increased significantly (P < 0.05), and the content of MDA decreased significantly (P < 0.05).
Conclusion: Curcumin can improve the antioxidant activity of the mice with acute alcoholism, and has good protective effects on acute alcoholic liver injury in mice.