The significance of serum phosphate level on healing index and its relative effects in skeletally immature and mature patients with hypophosphatemic rickets

Biomed Res Int. 2014:2014:569530. doi: 10.1155/2014/569530. Epub 2014 Apr 24.

Abstract

The aim of this study was to find out the ideal cut-off level of phosphate for safe healing when deformity correction and concomitant lengthening are indicated in the two different skeletal maturity groups of patients with rickets. Thirty-nine hypophosphatemic rickets patients were selected for the study and were divided into two groups: 27 skeletally immature (group IM) and 12 skeletally mature (group M). The outcomes were evaluated with respect to the healing index (HI), laboratory findings, and complications with the mean follow-up of 5.1 years (range, 3.1-7.9). The healing index (HI) of group IM was 1.44 month/cm and HI of group M was 1.68 month/cm. The negative correlation between the level of serum phosphate and HI in group M (coefficient=-0.94) was evaluated to be less than the correlation in group IM (coefficient=-0.50), indicating that the HI is more likely to be affected by serum phosphate in group M than in group IM. Preoperative serum phosphate levels of 2.3 mg/dL and 2.6 mg/dL were analyzed to be the cut-off values of group IM and group M, respectively, in which the cut-off points divided the series into two groups having the most significantly different HI.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Child
  • Child, Preschool
  • Female
  • Femur / pathology
  • Humans
  • Male
  • Phosphates / blood*
  • Retrospective Studies
  • Rickets, Hypophosphatemic / blood*
  • Tibia / pathology
  • Young Adult

Substances

  • Phosphates