Context: The size of nanoparticles plays a pivotal role in determining the gene delivery efficiency.
Objective: A focus on the studies done to investigate the effect of nanoparticles size on biological aspects of gene delivery.
Methods: A through literature survey has been done regarding studies done to investigate the effect of nanoparticles size on uptake, transfection efficiency and biodistribution has been cited in the present review.
Results and conclusion: The gene delivery efficacy may depend on conjugation of several factors such as the chemical structure of polymers, cell type, and nanoparticle size, composition and interaction with cells.
Keywords: biodistribution; cellular uptake; complexes; cytotoxicity; nanoparticles; transfection.