Hierarchical porous bioactive glasses/PLGA-magnetic SBA-15 for dual-drug release

Mater Sci Eng C Mater Biol Appl. 2014 Jun 1:39:21-8. doi: 10.1016/j.msec.2014.01.060. Epub 2014 Feb 10.

Abstract

The hierarchical porous bioglass combined with magnetic SBA-15 was synthesized. The bioactive glass materials possess a hierarchical porous structure with the macroporous (50μm) and the mesoporous (3.86nm) structures derived from the plant template (cattail stem) and triblock polyethylene oxide-propylene oxide block copolymer (P123), respectively. Magnetic SBA-15 was synthesized by adopting the post assembly method using Fe(NO3)3 as iron source and ethylene glycol as reduction. After coating PLGA, PLGA-IBU-magnetic SBA-15 also possessed super-paramagnetism and the corresponding saturation magnetizations (Ms) could reach 2.6emug(-1). Metformin HCl (MH) and ibuprofen (IBU) were used as model drugs, and the drug release kinetics was studied. MH and IBU could release 60% and 85% from the sample respectively. The system shows excellent dual-drug controlled delivery performance and good bioactivity in vitro that leads to good potential application on bone regeneration.

Keywords: Controlled release; Dual-drug; Hierarchical porous bioglasses; Magnetic SBA-15.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Ceramics / chemistry*
  • Drug Delivery Systems / methods*
  • Drug Liberation
  • Durapatite / chemistry
  • HeLa Cells
  • Humans
  • Hydrogen Bonding
  • Ibuprofen / chemistry
  • Lactic Acid / chemistry*
  • Magnetics
  • Metformin / chemistry
  • Microscopy, Electron, Scanning
  • Polyglycolic Acid / chemistry*
  • Polylactic Acid-Polyglycolic Acid Copolymer
  • Porosity
  • Silicon Dioxide / chemical synthesis*
  • Silicon Dioxide / pharmacology

Substances

  • Bioglass
  • SBA-15
  • Polylactic Acid-Polyglycolic Acid Copolymer
  • Polyglycolic Acid
  • Lactic Acid
  • Silicon Dioxide
  • Metformin
  • Durapatite
  • Ibuprofen