PLA/chitosan/keratin composites for biomedical applications

Mater Sci Eng C Mater Biol Appl. 2014 Jul 1:40:242-7. doi: 10.1016/j.msec.2014.03.054. Epub 2014 Mar 31.

Abstract

Novel composites based on PLA, chitosan and keratin was obtained via blend preparation. The goal of this contribution was to evaluate mechanical and in vitro behavior of the composites. The results point out composites with improved Young modulus and decreased tensile strength, significant increase in hardness (compared to PLA) and a good uptake of the surface properties. Biological assessments using human osteosarcoma cell line on these composites indicate a good viability/proliferation outcome. Hence preliminary results regarding mechanical behavior and in vitro osteoblast response suggest that these composites might have prospective application in medical field.

Keywords: Biomaterials; Chitosan; In vitro studies; Keratin; Mechanical properties; PLA.

MeSH terms

  • Biocompatible Materials / chemistry
  • Biocompatible Materials / pharmacology
  • Cell Line
  • Cell Survival / drug effects
  • Chitosan / chemistry*
  • Elastic Modulus
  • Hardness
  • Humans
  • Keratins / chemistry*
  • Lactic Acid / chemistry*
  • Polyesters
  • Polymers / chemistry*
  • Surface Properties
  • Tensile Strength

Substances

  • Biocompatible Materials
  • Polyesters
  • Polymers
  • Lactic Acid
  • poly(lactide)
  • Keratins
  • Chitosan