Objective: To explore the independent risk factors for the 1 year stroke event in Chinese patients with atrial fibrillation (AF) and hypertension (HT).
Methods: Data of AF and HT patients in the Chinese Emergency Atrial Fibrillation Registry Study were retrospectively analyzed. The eligible patients were divided into the stroke group and the non-stroke group according to the result of 1 year follow-up. The predictors for the 1 year stroke event were identified by uni- and multi-variate Cox regression analysis with the baseline and therapeutic variables.
Results: A total of 1 118 AF and HT patients were enrolled in the study with the incidence of 1 year stroke event of 8.7%. All patients were divided into the stroke group (n = 97) and the non-stroke group (n = 1 021). Compared with the non-stroke group, more female patients were in the stroke group (68.0% vs 54.5%, P < 0.05) and the patients in the stroke group were older [(76.0 ± 9.4) years vs (71.9 ± 10.6) years, P < 0.01] with higher proportion of previous history of stroke (38.1% vs 23.8%, P < 0.01). More patients were observed on the antihypertensive treatment in the non-stroke group (91.6% vs 85.6%, P < 0.05), while more patients on statins in the stroke group (45.4% vs 34.5%, P < 0.05). Multi-variate Cox regression analysis showed that age (HR = 1.036, 95%CI 1.010-1.062), female (HR = 1.908, 95%CI 1.170-3.110), previous stroke history (HR = 1.680, 95%CI 1.084-2.603), and no antihypertensive treatment (HR = 1.955, 95%CI 1.008-3.791) were independent risk factors for the 1 year stroke event in patients with AF and HT.
Conclusion: Age, female, previous stroke history and no antihypertensive treatment are the independent risk factors for the 1 year stroke event in patients with AF and HT.