Cationic amphiphilic non-hemolytic polyacrylates with superior antibacterial activity

Ashish Punia; Edward He; Kevin Lee; Probal Banerjee; Nan-Loh Yang

doi:10.1039/c4cc01583e

Cationic amphiphilic non-hemolytic polyacrylates with superior antibacterial activity

Chem Commun (Camb). 2014 Jul 7;50(53):7071-4. doi: 10.1039/c4cc01583e.

Authors

Ashish Punia¹, Edward He, Kevin Lee, Probal Banerjee, Nan-Loh Yang

Affiliation

¹ Center for Engineered Polymeric Materials, Department of Chemistry, College of Staten Island, City University of New York, 2800 Victory Blvd, Staten Island, New York 10314, USA. NanLoh.Yang-cepm@csi.cuny.edu.

PMID: 24854366
DOI: 10.1039/c4cc01583e

Abstract

Acrylic copolymers with appropriate compositions of counits having cationic charge with 2-carbon and 6-carbon spacer arms can show superior antibacterial activities with concomitant very low hemolytic effect. These amphiphilic copolymers represent one of the most promising synthetic polymer antibacterial systems reported.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acrylic Resins / chemical synthesis*
Acrylic Resins / chemistry
Animals
Anti-Bacterial Agents / chemical synthesis*
Anti-Bacterial Agents / chemistry
Cell Membrane / drug effects
Erythrocytes / drug effects
Escherichia coli / drug effects
Hemolysis / drug effects
In Vitro Techniques
Mice
Microbial Sensitivity Tests
Staphylococcus aureus / drug effects

Substances

Acrylic Resins
Anti-Bacterial Agents
carbopol 940