Three dimensional human small intestine models for ADME-Tox studies

Jiajie Yu; Rebecca L Carrier; John C March; Linda G Griffith

doi:10.1016/j.drudis.2014.05.003

Three dimensional human small intestine models for ADME-Tox studies

Drug Discov Today. 2014 Oct;19(10):1587-94. doi: 10.1016/j.drudis.2014.05.003. Epub 2014 May 20.

Authors

Jiajie Yu¹, Rebecca L Carrier², John C March³, Linda G Griffith⁴

Affiliations

¹ Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
² Department of Chemical Engineering, Northeastern University, Boston, MA, USA.
³ Department of Biological and Environmental Engineering, Cornell University, Ithaca, NY, USA.
⁴ Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. Electronic address: griff@mit.edu.

PMID: 24853950
DOI: 10.1016/j.drudis.2014.05.003

Abstract

In vitro human small intestine models play a crucial part in preclinical drug development. Although conventional 2D systems possess many advantages, such as facile accessibility and high-throughput capability, they can also provide misleading results due to their relatively poor recapitulation of in vivo physiology. Significant progress has recently been made in developing 3D human small intestine models, suggesting that more-reliable preclinical results could be obtained by recreating the 3D intestinal microenvironment in vitro. Although there are still many challenges, 3D human small intestine models have the potential to facilitate drug screening and drug development.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Animals
Drug Evaluation, Preclinical
Drug-Related Side Effects and Adverse Reactions
Humans
Intestine, Small / metabolism*
Models, Biological*
Pharmacokinetics