Adverse reaction to sublingual Parietaria vaccine following an ultra-rush induction

Eur Ann Allergy Clin Immunol. 2014 May;46(3):116-8.

Abstract

In the treatment of respiratory allergies Sublingual Immunotherapy (SLIT) represents a valid alternative to Subcutaneous Immunotherapy (SCIT) for its better safety profile. We describe a case of acute severe asthma following the first maintenance dose of SLIT in a boy allergic to Parietaria pollen. At the initiation of therapy, the patient was in healthy condition and his asthma appeared to be under control. An ultra-rush induction had given no reaction. Despite the good safety profile of SLIT, clinicians should be aware of the risk of adverse effects when prescribing SLIT for respiratory allergies.

Keywords: Parietaria; Pellitory; SLIT; adverse effects; asthma.

Publication types

  • Case Reports

MeSH terms

  • Acute Disease
  • Administration, Sublingual
  • Antigens, Plant / administration & dosage
  • Antigens, Plant / adverse effects*
  • Asthma / chemically induced*
  • Asthma / diagnosis
  • Asthma / immunology
  • Child
  • Drug Administration Schedule
  • Humans
  • Male
  • Parietaria / immunology*
  • Rhinitis, Allergic, Seasonal / diagnosis
  • Rhinitis, Allergic, Seasonal / immunology
  • Rhinitis, Allergic, Seasonal / therapy*
  • Risk Factors
  • Severity of Illness Index
  • Sublingual Immunotherapy / adverse effects*
  • Vaccines / administration & dosage
  • Vaccines / adverse effects*

Substances

  • Antigens, Plant
  • Vaccines