Antecollis and levodopa-responsive parkinsonism are late features of Dravet syndrome

Alfonso Fasano; Felippe Borlot; Anthony E Lang; Danielle M Andrade

doi:10.1212/WNL.0000000000000521

Antecollis and levodopa-responsive parkinsonism are late features of Dravet syndrome

Neurology. 2014 Jun 17;82(24):2250-1. doi: 10.1212/WNL.0000000000000521. Epub 2014 May 21.

Authors

Alfonso Fasano¹, Felippe Borlot¹, Anthony E Lang¹, Danielle M Andrade²

Affiliations

¹ From Toronto Western Hospital (A.F., F.B., A.E.L., D.M.A.), University of Toronto; The Edmond J. Safra Program in Parkinson's Disease (A.F., A.E.L.), Toronto; and The Hospital for Sick Children (F.B., D.M.A.), University of Toronto, Canada.
² From Toronto Western Hospital (A.F., F.B., A.E.L., D.M.A.), University of Toronto; The Edmond J. Safra Program in Parkinson's Disease (A.F., A.E.L.), Toronto; and The Hospital for Sick Children (F.B., D.M.A.), University of Toronto, Canada. danielle.andrade@uhn.ca.

Abstract

Dravet syndrome (DS) is a severe genetic epileptic encephalopathy mainly caused by SCN1A mutations.¹ Children usually develop frequent and pharmacoresistant seizures of several types. Besides cognitive delay, some patients later develop gait ataxia. “Crouch gait” has also been described in older patients.^2,3

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antiparkinson Agents / adverse effects*
Epilepsies, Myoclonic / complications*
Epilepsies, Myoclonic / genetics
Female
Gait Disorders, Neurologic / etiology
Humans
Levodopa / adverse effects*
Male
Parkinsonian Disorders / drug therapy*
Parkinsonian Disorders / etiology*
Sensation Disorders
Statistics, Nonparametric
Videotape Recording

Substances

Antiparkinson Agents
Levodopa