Development of oxacillin resistance in a patient with recurrent Staphylococcus aureus bacteremia

J Clin Microbiol. 2014 Aug;52(8):3114-7. doi: 10.1128/JCM.00615-14. Epub 2014 May 21.

Abstract

Whole-genome sequencing was used to compare longitudinal isolates of Staphylococcus aureus that developed resistance to oxacillin (MIC up to 16 μg/ml). The mecA gene was absent. A novel 5-bp TATCC frameshift insertion in a gene encoding an ABC transporter similar to that of the teichoic acid translocation ATP-binding protein TagH and a 3-bp GCT nonframeshift insertion in the pdhA pyruvate dehydrogenase gene were detected in the oxacillin-resistant isolates.

Publication types

  • Case Reports

MeSH terms

  • ATP-Binding Cassette Transporters / genetics
  • Aged, 80 and over
  • Anti-Bacterial Agents / pharmacology*
  • Bacteremia / microbiology*
  • DNA, Bacterial / chemistry
  • DNA, Bacterial / genetics
  • Drug Resistance, Bacterial*
  • Frameshift Mutation
  • Genome, Bacterial
  • Humans
  • Longitudinal Studies
  • Male
  • Microbial Sensitivity Tests
  • Molecular Sequence Data
  • Mutagenesis, Insertional
  • Oxacillin / pharmacology*
  • Recurrence
  • Sequence Analysis, DNA
  • Staphylococcal Infections / microbiology*
  • Staphylococcus aureus / drug effects*
  • Staphylococcus aureus / isolation & purification

Substances

  • ATP-Binding Cassette Transporters
  • Anti-Bacterial Agents
  • DNA, Bacterial
  • Oxacillin

Associated data

  • SRA/SRP042337