Serum β-nerve growth factor concentrations in pregnant female, nonpregnant female, and male cynomolgus monkeys

Hendrik Neubert; Tracey H Clark; Shibing Deng; Susan I Hurst

doi:10.1097/WNR.0000000000000187

Serum β-nerve growth factor concentrations in pregnant female, nonpregnant female, and male cynomolgus monkeys

Neuroreport. 2014 Aug 6;25(11):829-832. doi: 10.1097/WNR.0000000000000187.

Authors

Hendrik Neubert¹, Tracey H Clark², Shibing Deng³, Susan I Hurst²

Affiliations

¹ Pfizer Inc., Pharmacokinetics Dynamics and Metabolism, Andover, Massachusetts.
² Pfizer Inc., Pharmacokinetics Dynamics and Metabolism, Groton, Connecticut.
³ Pfizer Inc., Clinical Statistics, San Diego, California, USA.

PMID: 24848615
DOI: 10.1097/WNR.0000000000000187

Abstract

Serum β-nerve growth factor (NGF) concentrations were determined in pregnant female, nonpregnant female, and male cynomolgus monkeys using a highly selective and sensitive immunoaffinity liquid chromatography-tandem mass spectrometry assay. NGF was significantly higher in pregnant monkeys than in nonpregnant female and male monkeys. NGF increased over pregnancy (mean NGF±SD: 541±448, 1590±520, and 3560±1430 pg/ml during the first, second, and third trimesters, respectively). These data will aid in further understanding the role of NGF during pregnancy.