Abstract
This article assesses the value of animal models in determining the mechanism of action and spectrum of activity of cytokines. It examines the merits of animal models of transplantable and metastatic tumours and the value of human xenografts grown in immunodeficient mice and discusses how well they compare with the human situation. Results from the use of five cytokines in animal models of cancer are presented.
MeSH terms
-
Animals
-
Biological Factors / therapeutic use*
-
Cytokines
-
Disease Models, Animal
-
Drug Evaluation, Preclinical
-
Interferons / therapeutic use
-
Interleukins / therapeutic use
-
Mice
-
Neoplasm Metastasis
-
Neoplasm Transplantation
-
Neoplasms, Experimental / therapy*
-
Rats
-
Transplantation, Heterologous
-
Tumor Necrosis Factor-alpha / therapeutic use
Substances
-
Biological Factors
-
Cytokines
-
Interleukins
-
Tumor Necrosis Factor-alpha
-
Interferons