Regulating the regulator of ROS production

Marcelo G Bonini; Asrar B Malik

doi:10.1038/cr.2014.66

Regulating the regulator of ROS production

Cell Res. 2014 Aug;24(8):908-9. doi: 10.1038/cr.2014.66. Epub 2014 May 20.

Authors

Marcelo G Bonini¹, Asrar B Malik²

Affiliations

¹ 1] Department of Pharmacology, The University of Illinois College of Medicine, 835 South Wolcott Avenue, Chicago, IL 60612, USA [2] Department of Medicine, The University of Illinois College of Medicine, 835 South Wolcott Avenue, Chicago, IL 60612, USA [3] Department of Pathology, The University of Illinois College of Medicine, 835 South Wolcott Avenue, Chicago, IL 60612, USA.
² 1] Department of Pharmacology, The University of Illinois College of Medicine, 835 South Wolcott Avenue, Chicago, IL 60612, USA [2] Center for Lung and Vascular Biology, The University of Illinois College of Medicine, 835 South Wolcott Avenue, Chicago, IL 60612, USA.

Abstract

Balancing inflammatory reactive oxygen species (ROS) production is essential for safely eliminating pathogenic microbes. The newly described protein Negative Regulator of ROS (NRROS) dampens ROS production by restricting NOX2 availability, and thus "cools-off" inflammation.

Publication types

Comment

MeSH terms

Animals
Encephalomyelitis, Autoimmune, Experimental / immunology*
Encephalomyelitis, Autoimmune, Experimental / metabolism*
Escherichia coli / immunology*
Female
Listeria monocytogenes / immunology*
Male
Proteins / metabolism*
Reactive Oxygen Species / antagonists & inhibitors*

Substances

Proteins
Reactive Oxygen Species