Paper-based DNA detection using lanthanide-doped LiYF4 upconversion nanocrystals as bioprobe

Small. 2014 Oct 15;10(19):3912-7. doi: 10.1002/smll.201400683. Epub 2014 May 16.

Abstract

A novel sensitive DNA bioassay using lanthanide-doped LiYF4 upconversion nanocrystals as luminescent marker and oligonucleotide hybridization as the selective reaction is developed in a paper-based platform, providing a detection limit of 3.6 fmol.

Keywords: DNA detection; bioprobes; paper-based; upconversion.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biosensing Techniques*
  • DNA / chemistry*
  • Lanthanoid Series Elements / chemistry*
  • Light
  • Limit of Detection
  • Luminescence
  • Microscopy, Electron, Transmission
  • Nanoparticles / chemistry*
  • Nanotechnology
  • Oligonucleotides / chemistry
  • Optics and Photonics
  • Paper*
  • Photons
  • Scattering, Radiation
  • Spectroscopy, Near-Infrared
  • X-Ray Diffraction

Substances

  • Lanthanoid Series Elements
  • Oligonucleotides
  • DNA