The relationships between clinical characteristics, alcohol and psychotropic exposure, and circadian gene expression in human postmortem samples of affective disorder and control subjects

Psychiatry Res. 2014 Aug 30;218(3):359-62. doi: 10.1016/j.psychres.2014.04.048. Epub 2014 May 9.

Abstract

Circadian abnormalities may be related to mood disorders. Circadian gene expression was measured in postmortem brain tissue from individuals with affective disorders and controls. Relationships between circadian gene expression, clinical characteristics, and alcohol and psychotropic medication use were noted. Further study is warranted to characterize these relationships.

Keywords: Bipolar disorder; Circadian genes; Major depressive disorder.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Alcohol Drinking / genetics*
  • Autopsy
  • Bipolar Disorder / genetics*
  • Bipolar Disorder / pathology
  • Brain / pathology
  • Case-Control Studies
  • Circadian Clocks / genetics
  • Circadian Rhythm / genetics*
  • Depressive Disorder, Major / genetics*
  • Depressive Disorder, Major / pathology
  • Female
  • Gene Expression
  • Gene Expression Profiling
  • Humans
  • Male
  • Mood Disorders / genetics*
  • Mood Disorders / pathology*
  • Period Circadian Proteins / genetics*
  • Postmortem Changes
  • Reference Values

Substances

  • Period Circadian Proteins