Abstract
Circadian abnormalities may be related to mood disorders. Circadian gene expression was measured in postmortem brain tissue from individuals with affective disorders and controls. Relationships between circadian gene expression, clinical characteristics, and alcohol and psychotropic medication use were noted. Further study is warranted to characterize these relationships.
Keywords:
Bipolar disorder; Circadian genes; Major depressive disorder.
Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Alcohol Drinking / genetics*
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Autopsy
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Bipolar Disorder / genetics*
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Bipolar Disorder / pathology
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Brain / pathology
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Case-Control Studies
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Circadian Clocks / genetics
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Circadian Rhythm / genetics*
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Depressive Disorder, Major / genetics*
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Depressive Disorder, Major / pathology
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Female
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Gene Expression
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Gene Expression Profiling
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Humans
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Male
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Mood Disorders / genetics*
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Mood Disorders / pathology*
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Period Circadian Proteins / genetics*
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Postmortem Changes
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Reference Values
Substances
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Period Circadian Proteins