IL-22 gets to the stem of colorectal cancer

Immunity. 2014 May 15;40(5):639-41. doi: 10.1016/j.immuni.2014.04.014.

Abstract

Cytokines can provide survival and proliferation signals to cancer cells, thus promoting tumor progression. In this issue of Immunity, Kryczek et al. (2014) reveal that interleukin-22 can also promote "stemness" in human colorectal cancer via transcription factor STAT3-mediated epigenetic regulation of stem cell genes.

Publication types

  • Comment

MeSH terms

  • Animals
  • CD4-Positive T-Lymphocytes / immunology*
  • Colorectal Neoplasms / immunology*
  • Histone-Lysine N-Methyltransferase
  • Humans
  • Interleukin-22
  • Interleukins / immunology*
  • Methyltransferases / immunology*
  • Neoplastic Stem Cells / immunology*
  • STAT3 Transcription Factor / immunology*

Substances

  • Interleukins
  • STAT3 Transcription Factor
  • STAT3 protein, human
  • DOT1L protein, human
  • Methyltransferases
  • Histone-Lysine N-Methyltransferase