Abstract
Cytokines can provide survival and proliferation signals to cancer cells, thus promoting tumor progression. In this issue of Immunity, Kryczek et al. (2014) reveal that interleukin-22 can also promote "stemness" in human colorectal cancer via transcription factor STAT3-mediated epigenetic regulation of stem cell genes.
Copyright © 2014 Elsevier Inc. All rights reserved.
MeSH terms
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Animals
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CD4-Positive T-Lymphocytes / immunology*
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Colorectal Neoplasms / immunology*
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Histone-Lysine N-Methyltransferase
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Humans
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Interleukin-22
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Interleukins / immunology*
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Methyltransferases / immunology*
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Neoplastic Stem Cells / immunology*
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STAT3 Transcription Factor / immunology*
Substances
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Interleukins
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STAT3 Transcription Factor
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STAT3 protein, human
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DOT1L protein, human
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Methyltransferases
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Histone-Lysine N-Methyltransferase