Abstract
The inappropriate expansion of self-reactive "bystander" T cells can contribute to autoimmune disease. In this issue of Immunity, Watanabe et al. (2014) demonstrate that the tumor suppressor p53 prevents the cytokine-dependent proliferation of T cells in the absence of cognate antigens.
Copyright © 2014 Elsevier Inc. All rights reserved.
MeSH terms
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Animals
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CD4-Positive T-Lymphocytes / immunology*
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Interleukin-2 / immunology*
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Proto-Oncogene Proteins c-mdm2 / genetics*
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Receptors, Antigen, T-Cell / immunology*
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Tumor Suppressor Protein p53 / genetics*
Substances
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Interleukin-2
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Receptors, Antigen, T-Cell
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Tumor Suppressor Protein p53
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Mdm2 protein, mouse
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Proto-Oncogene Proteins c-mdm2