p53 keeps bystanders at the gates

Immunity. 2014 May 15;40(5):633-5. doi: 10.1016/j.immuni.2014.05.001.

Abstract

The inappropriate expansion of self-reactive "bystander" T cells can contribute to autoimmune disease. In this issue of Immunity, Watanabe et al. (2014) demonstrate that the tumor suppressor p53 prevents the cytokine-dependent proliferation of T cells in the absence of cognate antigens.

Publication types

  • Comment

MeSH terms

  • Animals
  • CD4-Positive T-Lymphocytes / immunology*
  • Interleukin-2 / immunology*
  • Proto-Oncogene Proteins c-mdm2 / genetics*
  • Receptors, Antigen, T-Cell / immunology*
  • Tumor Suppressor Protein p53 / genetics*

Substances

  • Interleukin-2
  • Receptors, Antigen, T-Cell
  • Tumor Suppressor Protein p53
  • Mdm2 protein, mouse
  • Proto-Oncogene Proteins c-mdm2