Abstract
We evaluated the correlation between fluoroquinolone use, measured by doses administered and days of therapy, with the emergence of ciprofloxacin and levofloxacin resistance among Gram-negative bacilli infections in children hospitalized at one pediatric center between April 2001 and March 2009. Both metrics and drug resistance were highly correlated.
MeSH terms
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Anti-Bacterial Agents / administration & dosage
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Anti-Bacterial Agents / pharmacology*
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Child
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Child, Preschool
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Drug Resistance, Bacterial
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Fluoroquinolones / administration & dosage
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Fluoroquinolones / pharmacology*
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Gram-Negative Bacteria / drug effects
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Gram-Negative Bacterial Infections / drug therapy*
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Gram-Negative Bacterial Infections / microbiology*
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Hospitalization
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Humans
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Infant
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Microbial Sensitivity Tests / methods
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Microbial Sensitivity Tests / standards*
Substances
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Anti-Bacterial Agents
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Fluoroquinolones