The quest for the best metric of antibiotic use and its correlation with the emergence of fluoroquinolone resistance in children

Pediatr Infect Dis J. 2014 Jun;33(6):e158-61. doi: 10.1097/INF.0000000000000238.

Abstract

We evaluated the correlation between fluoroquinolone use, measured by doses administered and days of therapy, with the emergence of ciprofloxacin and levofloxacin resistance among Gram-negative bacilli infections in children hospitalized at one pediatric center between April 2001 and March 2009. Both metrics and drug resistance were highly correlated.

MeSH terms

  • Anti-Bacterial Agents / administration & dosage
  • Anti-Bacterial Agents / pharmacology*
  • Child
  • Child, Preschool
  • Drug Resistance, Bacterial
  • Fluoroquinolones / administration & dosage
  • Fluoroquinolones / pharmacology*
  • Gram-Negative Bacteria / drug effects
  • Gram-Negative Bacterial Infections / drug therapy*
  • Gram-Negative Bacterial Infections / microbiology*
  • Hospitalization
  • Humans
  • Infant
  • Microbial Sensitivity Tests / methods
  • Microbial Sensitivity Tests / standards*

Substances

  • Anti-Bacterial Agents
  • Fluoroquinolones