Abstract
A novel benzoylphloroglucinol derivative, garcimultiflorone G (1), was isolated from the fruits of Garcinia multiflora. The structure of 1 was determined through extensive 1D- and 2D-NMR, and MS analyses. Garcimultiflorone G (1) showed inhibitory effects against superoxide anion (O·2(-) generation and elastase release by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B (fMLP/CB), with IC50 values of 6.97 ± 1.56 and 11.70 ± 1.58 μM, respectively.
Keywords:
Biological activity; Garcimultiflorone G; Garcinia multiflora.
Copyright © 2014 Verlag Helvetica Chimica Acta AG, Zürich.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Inflammatory Agents / chemistry
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Anti-Inflammatory Agents / isolation & purification
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Anti-Inflammatory Agents / pharmacology*
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Garcinia / chemistry*
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Heterocyclic Compounds, 4 or More Rings / chemistry
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Heterocyclic Compounds, 4 or More Rings / isolation & purification
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Heterocyclic Compounds, 4 or More Rings / pharmacology*
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Humans
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N-Formylmethionine Leucyl-Phenylalanine / immunology
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Neutrophils / drug effects*
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Neutrophils / immunology
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Pancreatic Elastase / immunology
Substances
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Anti-Inflammatory Agents
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Heterocyclic Compounds, 4 or More Rings
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garcimultiflorone G
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N-Formylmethionine Leucyl-Phenylalanine
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Pancreatic Elastase