Garcimultiflorone G, a novel benzoylphloroglucinol derivative from Garcinia multiflora with inhibitory activity on neutrophil pro-inflammatory responses

Chem Biodivers. 2014 May;11(5):819-24. doi: 10.1002/cbdv.201300278.

Abstract

A novel benzoylphloroglucinol derivative, garcimultiflorone G (1), was isolated from the fruits of Garcinia multiflora. The structure of 1 was determined through extensive 1D- and 2D-NMR, and MS analyses. Garcimultiflorone G (1) showed inhibitory effects against superoxide anion (O·2(-) generation and elastase release by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B (fMLP/CB), with IC50 values of 6.97 ± 1.56 and 11.70 ± 1.58 μM, respectively.

Keywords: Biological activity; Garcimultiflorone G; Garcinia multiflora.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Inflammatory Agents / chemistry
  • Anti-Inflammatory Agents / isolation & purification
  • Anti-Inflammatory Agents / pharmacology*
  • Garcinia / chemistry*
  • Heterocyclic Compounds, 4 or More Rings / chemistry
  • Heterocyclic Compounds, 4 or More Rings / isolation & purification
  • Heterocyclic Compounds, 4 or More Rings / pharmacology*
  • Humans
  • N-Formylmethionine Leucyl-Phenylalanine / immunology
  • Neutrophils / drug effects*
  • Neutrophils / immunology
  • Pancreatic Elastase / immunology

Substances

  • Anti-Inflammatory Agents
  • Heterocyclic Compounds, 4 or More Rings
  • garcimultiflorone G
  • N-Formylmethionine Leucyl-Phenylalanine
  • Pancreatic Elastase