Two new avermectin derivatives, avermectins B1c and B1e (1 and 2, resp.), as well as two known compounds, avermectin B2a (3) and ivermectin A1a (4), were isolated from a Beibu Gulf gorgonian coral, Anthogorgia caerulea. The structures of the new compounds were established by detailed spectroscopic analysis and by comparison with spectral data of related known compounds. Compounds 1-4 showed moderate antifouling activities against the larval settlement of Balanus amphitrite.
Keywords: Anthogorgia caerulea; Antifouling activity; Avermectins B1c and B1e.
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