Two new avermectin derivatives from the Beibu Gulf gorgonian Anthogorgia caerulea

Chem Biodivers. 2014 May;11(5):812-8. doi: 10.1002/cbdv.201300265.

Abstract

Two new avermectin derivatives, avermectins B1c and B1e (1 and 2, resp.), as well as two known compounds, avermectin B2a (3) and ivermectin A1a (4), were isolated from a Beibu Gulf gorgonian coral, Anthogorgia caerulea. The structures of the new compounds were established by detailed spectroscopic analysis and by comparison with spectral data of related known compounds. Compounds 1-4 showed moderate antifouling activities against the larval settlement of Balanus amphitrite.

Keywords: Anthogorgia caerulea; Antifouling activity; Avermectins B1c and B1e.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anthozoa / chemistry*
  • Biofouling / prevention & control*
  • Disinfectants / chemistry*
  • Disinfectants / isolation & purification
  • Disinfectants / metabolism
  • Ivermectin / analogs & derivatives*
  • Ivermectin / chemistry
  • Ivermectin / isolation & purification
  • Ivermectin / metabolism
  • Larva / drug effects
  • Larva / growth & development
  • Thoracica / drug effects*
  • Thoracica / growth & development

Substances

  • Disinfectants
  • abamectin
  • Ivermectin