Abstract
A simple, fast and efficient method for allylation and propargylation of chlorosilanes through zinc mediation and ultrasound promotion is reported. As a direct application of the resulting bis-allylsilanes, three novel, constrained sila amino acids are prepared for the first time. The design and synthesis of the constrained sila analogue of GABA (γ-amino butyric acid) is a highlight of this work.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acids / chemical synthesis*
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Amino Acids / chemistry
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Silanes / chemical synthesis*
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Silanes / chemistry
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Silicon / chemistry
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Ultrasonics / methods*
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Zinc / chemistry*
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gamma-Aminobutyric Acid / analogs & derivatives
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gamma-Aminobutyric Acid / chemical synthesis
Substances
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Amino Acids
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Silanes
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gamma-Aminobutyric Acid
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Zinc
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Silicon