A note on exact differences between beta distributions in genomic (Methylation) studies

PLoS One. 2014 May 13;9(5):e97349. doi: 10.1371/journal.pone.0097349. eCollection 2014.

Abstract

We apply a known algorithm for computing exactly inequalities between Beta distributions to assess whether a given position in a genome is differentially methylated across samples. We discuss the advantages brought by the adoption of this solution with respect to two approximations (Fisher's test and Z score). The same formalism presented here can be applied in a similar way to variant calling.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bayes Theorem
  • DNA Methylation / genetics*
  • Genome / genetics*
  • Genomics / methods
  • Models, Genetic*
  • Probability

Grants and funding

The authors would like to acknowledge the support provided by the Spanish Ministerio de Ciencia e Innovación (grant SAF2011-30391). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.