The wind god promotes lung cancer

Steven M Frisch; Michael D Schaller

doi:10.1016/j.ccr.2014.04.022

The wind god promotes lung cancer

Cancer Cell. 2014 May 12;25(5):551-2. doi: 10.1016/j.ccr.2014.04.022.

Authors

Steven M Frisch¹, Michael D Schaller²

Affiliations

¹ Department of Biochemistry and Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV 26506, USA. Electronic address: sfrisch@hsc.wvu.edu.
² Department of Biochemistry and Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV 26506, USA.

PMID: 24823631
DOI: 10.1016/j.ccr.2014.04.022

Abstract

In this issue of Cancer Cell, Li and colleagues demonstrate that the hematopoietic transcription factor Aiolos (named after the Wind God of Greek mythology) confers anoikis resistance in lung tumor cells through repression of cell adhesion-related genes including the mechanosensor p66Shc.

Publication types

Comment

MeSH terms

Carcinoma, Non-Small-Cell Lung / genetics*
Gene Expression Regulation, Neoplastic*
Gene Silencing*
Humans
Ikaros Transcription Factor / metabolism*
Lung Neoplasms / genetics*
Shc Signaling Adaptor Proteins / genetics*
Src Homology 2 Domain-Containing, Transforming Protein 1

Substances

IKZF3 protein, human
SHC1 protein, human
Shc Signaling Adaptor Proteins
Src Homology 2 Domain-Containing, Transforming Protein 1
Ikaros Transcription Factor