Congenital transmission of multidrug-resistant tuberculosis

Am J Trop Med Hyg. 2014 Jul;91(1):92-5. doi: 10.4269/ajtmh.13-0002. Epub 2014 May 12.

Abstract

This article presents a case of multidrug-resistant tuberculosis (TB) in a Peruvian infant. His mother was diagnosed with disseminated TB, and treatment commenced 11 days postpartum. The infant was diagnosed with TB after 40 days and died at 2 months and 2 days of age. Congenital transmission of TB to the infant was suspected, because direct postpartum transmission was considered unlikely; also, thorough screening of contacts for TB was negative. Spoligotyping confirmed that both mother and baby were infected with identical strains of the Beijing family (SIT1).

Publication types

  • Case Reports

MeSH terms

  • Antitubercular Agents / therapeutic use
  • Fatal Outcome
  • Female
  • Humans
  • Infant
  • Infectious Disease Transmission, Vertical*
  • Male
  • Mycobacterium tuberculosis / drug effects
  • Mycobacterium tuberculosis / pathogenicity
  • Tuberculosis, Multidrug-Resistant / drug therapy
  • Tuberculosis, Multidrug-Resistant / microbiology
  • Tuberculosis, Multidrug-Resistant / transmission*

Substances

  • Antitubercular Agents