Phomopsidone A, a novel depsidone metabolite from the mangrove endophytic fungus Phomopsis sp. A123

Wei Zhang; Liyan Xu; Lishan Yang; Yaojian Huang; Shengying Li; Yuemao Shen

doi:10.1016/j.fitote.2014.05.001

Phomopsidone A, a novel depsidone metabolite from the mangrove endophytic fungus Phomopsis sp. A123

Fitoterapia. 2014 Jul:96:146-51. doi: 10.1016/j.fitote.2014.05.001. Epub 2014 May 10.

Authors

Wei Zhang¹, Liyan Xu², Lishan Yang³, Yaojian Huang³, Shengying Li⁴, Yuemao Shen⁵

Affiliations

¹ Key Laboratory of Biofuels, Shandong Provincial Key Laboratory of Energy Genetics, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, No. 189 Songling Road, Qingdao, Shandong 266101, PR China; School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, PR China.
² School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, PR China; Basic Medicine College, Putian University, Putian, Fujian 351100, PR China.
³ School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, PR China.
⁴ Key Laboratory of Biofuels, Shandong Provincial Key Laboratory of Energy Genetics, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, No. 189 Songling Road, Qingdao, Shandong 266101, PR China.
⁵ School of Life Sciences, Shandong University, Jinan, Shandong 250100, PR China. Electronic address: yshen@sdu.edu.cn.

PMID: 24821321
DOI: 10.1016/j.fitote.2014.05.001

Abstract

One novel pentacyclic depsidone containing an oxetane unit, phomopsidone A (1), together with the reported excelsione (also named as phomopsidone) (2), and four known isobenzofuranones (3-6) were isolated from the mangrove endophytic fungus Phomopsis sp. A123. Their structures were elucidated by 1D and 2D NMR spectroscopic analysis and high resolution mass spectrometry. The bioactivity assays showed that these compounds possess cytotoxic, antioxidant, and antifungal activities.

Keywords: Cytotoxicity; Depsidones; Endophyte; Isobenzofuranones; Phomopsis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Infective Agents / chemistry
Anti-Infective Agents / isolation & purification*
Anti-Infective Agents / pharmacology
Ascomycota / chemistry*
Biphenyl Compounds / adverse effects
Cell Survival / drug effects
Depsides / chemistry
Depsides / isolation & purification*
Depsides / pharmacology
Endophytes
Free Radical Scavengers / chemistry
Free Radical Scavengers / isolation & purification*
Free Radical Scavengers / pharmacology
Lactones / chemistry
Lactones / isolation & purification*
Lactones / pharmacology
Magnetic Resonance Spectroscopy
Molecular Structure
Picrates / adverse effects
Rhizophoraceae / microbiology

Substances

Anti-Infective Agents
Biphenyl Compounds
Depsides
Free Radical Scavengers
Lactones
Picrates
excelsione
phomopsidone
depsidone
1,1-diphenyl-2-picrylhydrazyl